University of Tsukuba, Laboratory of Fungal Interaction and Molecular Biology

主な研究テーマ

• 糸状菌と他生物との相互作用応答とそのメカニズムの解明
• 病原糸状菌の薬剤応答と薬剤耐性機構の解明
• 糸状菌の二次代謝物、酵素ライブラリーの創成
• 糸状菌由来トキシン（カビ毒）の抑制技術の開発

連絡先

E-mail　:　hagiwara.daisuke.gb(at)u.tsukuba.ac.jp
　　　　※(at)を@にかえてください。

学歴

2006年　名古屋大学大学院　生命農学研究科　生物機構・機能科学専攻卒業（博士後期課程）
2003年　名古屋大学大学院　生命農学研究科　生物機構・機能科学専攻卒業（博士前期課程）
2000年　早稲田大学　理工学部　応用化学科卒業

職歴

2017年〜　現職
2011年〜2017年　千葉大学　真菌医学研究センター　特任助教
2010年～2011年　デンソー株式会社／中央大学　理工学部　博士研究員／機構助教
2007年～2010年　日本学術振興会　特別研究員　（東北大学　未来科学技術共同研究センター）
2006年～2007年　名古屋大学　農学部　博士研究員
2000年　一般企業

受賞歴

1.　2019年 日本医真菌学会奨励賞
2.　2016年 日本医真菌学会学術集会、優秀演題賞（発表者）
3.　2015年 日本医真菌学会学術集会、優秀演題賞（発表者）
4.　2015年 真菌症フォーラム、奨励賞（発表者）
5.　平成24年度 糸状菌遺伝子研究会　奨励賞
6.　2004年度　日本農芸化学会　BBB論文賞（筆頭筆者）

研究業績

1. Zhao Y-J, Shirouzu T, Chiba Y, Hosaka K, Moriyama H, Urayama SI*, Hagiwara D. Identification of novel RNA mycoviruses from wild mushroom isolates in Japan. Virus Research, 325: 199045 (2023)
   
   
2. Chiba Y, Yabuki A, Takaki Y, Nunoura T, Urayama S*, Hagiwara D*. The first identification of a narnavirus in Bigyra, a marine-protist. Microbes and Environments, 38: ME22077 (2023)
   
   
3. Ikeda A, Chiba Y, Kuroki M, Urayama S*, Hagiwara D*. Efficient elimination of RNA mycoviruses in Aspergillus species using RdRp-inhibitors ribavirin and 2'-C-methylribonucleoside derivatives. Frontiers in Microbiology, 13:1024933 (2022)
   
   
4. Kusuya Y, Bian C, Hagiwara D, Ban S, Takahashi H*. A novel Zn₂-Cys₆ transcription factor ClcA contributes to copper homeostasis in Aspergillus fumigatus. Current Genetics, 68: 605-617 (2022)
   
   
5. Bian C, Kusuya Y, Hagiwara D, Ban S, Lu Y, Nagayama M, Takahashi H*. Dysfunction of Ras-GAP protein AfgapA contributes to hypoxia fitness in Aspergillus fumigatus. Current Genetics, 68: 593-603 (2022)
   
   
6. Mizutani Y, Chiba Y, Urayama S, Tomaru Y, Hagiwara D, Kimura K*. Detection and Characterization of RNA Viruses in Red Macroalgae (Bangiaceae) and Their Food Product (Nori Sheets). Microbes and Environments 37.2 (2022): ME21084.
   
   
7. Oiki S, Nasuno R, Urayama S, Takagi H, Hagiwara D*. Intracellular production of reactive oxygen species and a DAF-FM-related compound in Aspergillus fumigatus in response to antifungal agent exposure. Scientific Reports, 12: 13516 (2022)
   
   
8. Ninomiya A, Urayama S, Hagiwara D*. Antibacterial diphenyl ether production induced by co-culture of Aspergillus nidulans and Aspergillus fumigatus. Applied Microbiology and Biotechnology, 106: 4169–4185 (2022)
   
   
9. Oiki S, Yaguchi T, Urayama S, Hagiwara D*. Wide distribution of resistance to the fungicides fludioxonil and iprodione in Penicillium species. PLoS One, 17.1: e0262521 (2022)
   
   
10. Nasuno R, Suzuki S, Oiki S, Hagiwara D, Takagi H*. Identification and functional analysis of GTP cyclohydrolase II in Candida glabrata in response to nitrosative stress. Frontiers in Microbiology, 13: 825121 (2022)
    
    
11. Chiba Y, Oiki S, Zhao Y-J, Nagano Y, Urayama S*, Hagiwara D*. Splitting of RNA-dependent RNA Polymerase is Common in Narnaviridae: Identification of a type II Divided-RdRp from Deep-Sea Fungal Isolates. Virus Evol. 7(2), veab095 (2021)
    
    
12. Takahashi H, Oiki S, Kusuya Y, Urayama S, Hagiwara D*. Intimate genetic relationships and fungicide resistance in multiple strains of Aspergillus fumigatus isolated from a plant bulb. Environmental Microbiology, 23: 5621-5638 (2021)（プレスリリース）
    
    
13. Trabasso P, Matsuzawa T, Arai T, Hagiwara D, Mikami Y, Moretti ML, Watanabe A. Development and validation of LAMP primer sets for rapid identification of Aspergillus fumigatus carrying the cyp51A TR₄₆ azole resistance gene. Sci. Rep. 11: 17087 (2021)
    
    
14. Toyotome T*, Onishi K, Sato M, Kusuya Y, Hagiwara D, Watanabe A, Takahashi H. Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole. Antimicrob Agents Chemother. 65: e02657-20 (2021)
    
    
15. Yoshimi A, Hagiwara D, Ono M, Fukuma Y, Midorikawa Y, Furukawa K, Fujioka T, Mizutani O, Sato N, Miyazawa K, Maruyama JI, Marui J, Yamagata Y, Nakajima T, Tanaka C, Abe K*. Downregulation of the ypdA gene encoding an intermediate of His-Asp phosphorelay signaling in Aspergillus nidulans induces the same cellular effects as the phenylpyrrole fungicide fludioxonil. Frontiers in Fungal Biology, 2: 675459 (2021)
    
    
16. Takahashi H, Umemura M, Ninomiya A, Kusuya Y, Shimizu M, Urayama S, Watanabe A, Kamei K, Yaguchi T, Hagiwara D*. Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati. Frontiers in Fungal Biology, 2: 656751. doi: 10.3389/ffunb.2021.656751 (2021)
    
    
17. Chiba Y, Oiki S, Yaguchi T, Urayama S*, Hagiwara D*. Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses. Virus Evol. 7(1), veaa101 (2020) （プレスリリース）
    
    
18. Tani S*, Nishio N, Kai K, Hagiwara D, Ogata Y, Tojo M, Sumitani JI, Judelson HS, Kawaguchi T. Chemical genetic approach using beta-rubromycin reveals that a RIO kinase-like protein is involved in morphological development in Phytophthora infestans. Sci. Rep. 10: 22326 (2020)
    
    
19. Takahashi-Nakaguchi A* , Shishido E, Yahara M, Urayama S, Ninomiya A, Chiba Y, Sakai K, Hagiwara D, Chibana H, Moriyama H, Gonoi T. Phenotypic and molecular biological analysis of polymycovirus AfuPmV-1M from Aspergillus fumigatus: Reduced fungal virulence in a mouse infection model. Front. Microbiol. 11: 607795 (2020)
    
    
20. Abeysinghe G, Kuchira M, Kudo G, Masuo S, Ninomiya A, Takahashi K, Utada A, Hagiwara D, Nomura N, Takaya N, Obana N*, Takeshita N*. Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism. Life Science Alliance, e202000878 (2020)（プレスリリース）（Science誌のEditors’ Choice）
    
    
21. Urayama S*, Doi N, Kondo F, Chiba Y, Takaki Y, Hirai M, Minegishi Y, Hagiwara D, Nunoura T. Diverged and active partitiviruses in lichen. Front. Microbiol. 11: 561344 (2020)
    
    
22. Morishita Y, Aoki Y, Ito M, Hagiwara D, Torimaru K, Morita D, Kuroda T, Fukano H, Hoshino Y, Suzuki M, Taniguchi T, Mori K, Asai T*. Genome mining-based discovery of fungal macrolides modified by GPI-ethanolamine phosphate transferase homologs. Org. Lett., 22: 5876-5879 (2020)
    
    
23. Ninomiya A, Urayama S, Suo R, Itoi S, Fuji S, Moriyama H, Hagiwara D*. Mycovirus-induced tenuazonic acid production in a rice blast fungus Magnaporthe oryzae. Front. Microbiol. 11: 1641 (2020)
    
    
24. Hagiwara D*. Isolation of azole-resistant Aspergillus fumigatus from imported plant bulbs in Japan and the effect of fungicide treatment. J. Pest. Sci.45: 147-150 (2020)
    (早期公開)
    https://www.jstage.jst.go.jp/article/jpestics/advpub/0/advpub_D20-017/_article/-char/ja
    
    
25. Chiba Y, Tomaru Y, Shimabukuro H, Kimura K, Hirai M, Takaki Y, Hagiwara D, Nunoura T, Urayama S *. Viral RNA genomes identified from marine macroalgae and a diatom. Microbes and Environments, 35(3): ME10016 (2020)
    
    
26. Tatara H, Sato Y, Kasai Y, Hagiwara D, Makino A, Imamura S, Abe J, Harayama S*. A method for the preparation of electrocompetent cells to transform unicellular green algae, Coccomyxa (Trebouxiophyceae, Chlorophyta) strains Obi and KJ. Algal Res., 48: 101904 (2020)
    
    
27. Urayama S*, Takaki Y, Hagiwara D, Nunoura T. dsRNA-seq reveals novel RNA virus and virus-like complete genome sequences from Hymeniacidon sp. sponge. Microbes and Environments. 35(2), ME19132 (2020)
    
    
28. Rocha M, Fabri J, Simões I, Silva-Rocha R, Hagiwara D, Cunha A, Goldman G, Cánovas D, and Malavazi I*. The cell wall integrity pathway contributes to the early stages of Aspergillus fumigatus asexual development. Appl. Environ. Microbiol., 86: e02347-19 (2020)
    
    
29. Chihara Y, Tanaka Y, Izumi M, Hagiwara D, Watanabe A, Takegawa K, Kamei K, Shibata N, Ohta K, Oka T*: Biosynthesis of β-(1→5)-galactofuranosyl chains of fungal-type and O-mannose-type galactomannans within the invasive pathogen Aspergillus fumigatus. mSphere, 5:e00770-19 (2020)
    
    
30. Sugahara A, Yoshimi A, Shoji F, Fujioka T, Kawai K, Umeyama H, Komatsu K, Enomoto M, Kuwahara S, Hagiwara D, Katayama T, Horiuchi H, Miyazawa K, Nakayama M, Abe K*: A Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi. Appl. Environ. Microbiol., 85:e02923-18 (2019) doi: 10.1128/AEM.02923-18.
    
    
31. Ries LN, Steenwyk JL, de Castro P, Borborema P, de Lima A, Almeida F, Jose de Assis L, Manfiolli A, Takahashi-Nakaguchi A, Kusuya Y, Hagiwara D, Takahashi H, Wang X, Obar JJ, Rokas A, Goldman GH*: Nutritional heterogeneity among Aspergillus fumigatus strains has consequences for virulence in a strain- and host-dependent manner. Front. Microbiol., 10:854 (2019) doi: 10.3389/fmicb.2019.00854
    
    
32. Paul S, Stamnes M, Thomas G, Liu H, Hagiwara D, Gomi K, Filler S, Moye-Rowley WS*: AtrR is an essential determinant of azole resistance in Aspergillus fumigatus. mBio, 10: e02563-18 (2019)
    
    
33. Onoue T, Tanaka Y, Hagiwara D, Ekino K, Watanabe A, Ohta K, Kamei K, Shibata N, Goto M, Oka T*: Identification of Two Mannosyltransferases Contributing to Biosynthesis of the Fungal-type Galactomannan α-Core-Mannan Structure in Aspergillus fumigatus. Sci. Rep., 8: 16918 (2018)
    
    
34. José de Assis L, Manfiolli A, Mattos E, Malavazi I, Jacobsen ID, Brock M, Cramer RA, Thammahong A, Hagiwara D, Ries LNA, Goldman GH*: Cooperation between protein kinase A (PKA) and high osmolarity glycerol (HOG) response pathways cooperatively control cell wall carbohydrate mobilization in Aspergillus fumigatus. mBio, 9:e01952-18 (2018)
    
    
35. Hagiwara D, Arai T, Takahashi H, Kusuya Y, Watanabe A*, Kamei K: Non-cyp51A azole-resistant Aspergillus fumigatus isolates with mutation in HMG-CoA reductase. Emerg. Infect. Dis., 24: 1889-1897 (2018)
    
    
36. Hagiwara D*, Takahashi H, Takagi H, Watanabe A, Kamei K: Heterogeneity in pathogenicity-related properties and stress tolerance in Aspergillus fumigatus clinical isolates. Med. Mycol. J., 59E: E63-E70 (2018)
    
    
37. Takahashi-Nakaguchi A, Sakai K, Takahashi H, Hagiwara D, Toyotome T, Chibana H, Watanabe A, Yaguchi T, Yamaguchi M, Kamei K, Gonoi T*: Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses. Cell. Microbiol., 3: e12802 (2018)
    
    
38. Toyotome T*, Hagiwara D, Watanabe A, Kamei K: A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus. Med. Mycol., 56: 1042-1044 (2018)
    
    
39. Takahashi H*, Kusuya Y, Hagiwara D, Takahashi-Nakaguchi A, Sakai K, Gonoi T: Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia. BMC Genomics, 18: 942 (2017)
    
    
40. Hashimoto A, Hagiwara D, Watanabe A*, Yahiro M, Yikelamu A, Yaguchi T, Kamei K: Drug sensitivity and resistance mechanism in Aspergillus section Nigri strains from Japan. Antimicrob. Agents Chemother., 61: e02583-16 (2017)
    
    
41. Kusuya Y, Hagiwara D, Sakai K, Yaguchi T, Gonoi T, Takahashi H*: Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus. Curr. Gent., 63: 777-789 (2017)
    
    
42. Toyotome T*, Hagiwara D, Kida H, Ogi T, Watanabe A, Wada T, Komatsu R, Kamei K: First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan. J. Infect. Chemother., 23: 579-581 (2017)
    
    
43. Hagiwara D*, Sakai K, Suzuki S, Umemura M, Nogawa T, Kato N, Osada H, Watanabe A, Kawamoto S, Gonoi T, Kamei K: Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus. PLoS One, 12: e0177050 (2017)
    
    
44. Onishi K, Sarumoh BM, Hagiwara D, Kamei K, Toyotome T*: Azole-resistant Aspergillus fumigatus containing a 34-bp tandem repeat in cyp51A promoter is isolated from the environment in Japan. Med. Mycol. J., 58E: E67-E70 (2017)
    
    
45. Silva LP, de Castro PA, Dos Reis TF, Paziani MH, Kress MR, Riaño-Pachón DM, Hagiwara D, Ries LN, Brown NA, Goldman GH*: Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA^HOG1 and MpkC dependent. Cell. Microbiol., 19: e12681 (2017)
    
    
46. Hagiwara D*, Miura D, Shimizu K, Paul S, Ohba A, Gonoi T, Watanabe A, Kamei K, Shintani T, Moye-Rowley WS, Kawamoto S, Gomi K*: A novel Zn₂-Cys₆ transcription factor AtrR plays a key role in an azole resistance mechanism of Aspergillus fumigatus by co-regulating cyp51A and cdr1B expressions. PLoS Pathogens, 13: e1006096 (2017)
    
    
47. Hagiwara D*, Watanabe A, Kamei K: Sensitisation of an azole-resistant Aspergillus fumigatus strain containing the Cyp51A-related mutation by deleting the SrbA gene. Scientific Reports, 6: 38833 (2016) 千葉大学ニュースリリース（>>こちら）
    
    
48. de Castro PA, Dos Reis TF, Dolan SK, Manfiolli AO, Brown NA, Jones GW, Doyle S, Riaño-Pachón DM, Squina FM, Caldana C, Singh A, Del Poeta M, Hagiwara D, Silva-Rocha R, Goldman GH*, The Aspergillus fumigatus SchA^SCH9 kinase modulates SakA^HOG1 MAP kinase activity and it is essential for virulence. Mol. Microbiol., 102: 642-671 (2016)
    
    
49. Hagiwara D*, Takahashi H, Kusuya Y, Kawamoto S, Kamei K, Gonoi T, Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: An essential role for AtfA in conidial dormancy. BMC Genomics, 17: 358 (2016)
    
    
50. Kunitake E, Hagiwara D, Miyamoto K, Kanamaru K, Kimura M, Kobayashi T*, Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans. Appl. Microbiol. Biotechnol., 100: 3621-3635 (2016)
    
    
51. De Oliveira Bruder-Nascimento AC, Dos Reis TF, de Castro PA, Hori JI, Bom VL, de Assis LJ, Ramalho LN, Rocha MC, Malavazi I, Brown NA, Valiante V, Brakhage AA, Hagiwara D, Goldman GH*, Mitogen activated protein kinases SakA^HOG1 and MpkC collaborate for Aspergillus fumigatus virulence. Mol. Microbiol., 100: 841-859 (2016)
    
    
52. Hagiwara D, Takahashi H, Fujimoto M, Sugawara M, Misawa Y, Gonoi T, Itoyama S, Watanabe A*, Kamei K, Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan. J. Infect. Chemother., 22: 577-579 (2016)
    
    
53. Bühler N, Hagiwara D, Takeshita N*, Functional analysis of sterol transporter orthologues (OSHs) in filamentous fungus Aspergillus nidulans. Eukaryot. Cell, 14. 908-921 (2015)
    
    
54. Winkelströter LK, Dolan SK, dos Reis TF, Bom VL, de Castro PA, Hagiwara D, Jones GW, Doyle S, Brown NA, Goldman GH*, Systematic global analysis of genes encoding protein phosphatases in Aspergillus fumigatus. G3, 5. 1525-1539 (2015)
    
    
55. Bom VL, de Castro PA, Winkelströter LK, Marine M, Hori JI, Ramalho LN, dos Reis TF, Goldman MH, Brown NA, Rajendran R, Ramage G, Walker LA, Munro CA, Rocha MC, Malavazi I, Hagiwara D, Goldman GH*, Aspergillus fumigatus sitA phosphatase homologue is important for adhesion, cell wall integrity, biofilm formation and virulence. Eukaryot. Cell, 14. 728-744 (2015)
    
    
56. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H*, Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med. Mycol., 53. 353-360 (2015)
    
    
57. Winkelströter LK, Bom VL, de Castro PA, Ramalho LN, Goldman MH, Brown NA, Rajendran R, Ramage G, Bovier E, dos Reis TF, Salvoldi M, Hagiwara D, Goldman GH*, High osmolarity glycerol response (HOG) PtcB phosphatase is important for Aspergillus fumigatus virulence. Mol. Microbiol., 96. 42-54 (2015)
    
    
58. Yoshimi A, Fujioka T, Mizutani O, Marui J, Hagiwara D, Abe K*, Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans. Biosci. Biotechnol. Biochem., 79. 836-844 (2015)
    
    
59. Shimizu K*, Nakagawa H, Hashimoto R, Hagiwara D, Onji Y, Asano K, Kawamoto S, Takahashi H, Yokoyama K, The α–oxoamine synthase gene fum8 is involved in fumonisin B2 biosynthesis in Aspergillus niger. Mycoscience, 56. 301-308 (2015)
    
    
60. Hagiwara D*, Suzuki S, Kamei K, Gonoi T, Kawamoto S, The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus. Fungal Genet. Biol., 73. 138-149 (2014)
    
    
61. Hagiwara D*, Takahashi H, Watanabe A, Takahashi-Nakaguchi A, Kawamoto S, Kamei K, Gonoi T, Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients infected with aspergillosis. J. Clin. Microbiol., 52. 4202-4209 (2014)
    
    
62. de Castro PA, Chen C, de Almeida RS, Freitas FZ, Bertoloni MC, Morais ER, Brown NA, Ramalho LN, Hagiwara D, Mitchell TK, Goldman GH*, ChIP-seq reveals a role for CrzA in the Aspergillus fumigatus High Osmolarity Glycerol Response (HOG) signaling pathway. Mol. Microbiol., 94. 655-674 (2014)
    
    
63. Hagiwara D*, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S, NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigtus. PLoS One, 8. e80881 (2013)
    
    
64. Yoshimi A, Sano M, Inaba A, Kokubun Y, Fujioka T, Mizutani O, Hagiwara D, Fujikawa T, Nishimura M, Yano S, Kasahara S, Shimizu K, Yamaguchi M, Kawakami K, Abe K*, Functional analysis of the α-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: AgsB is the major α-1,3-glucan synthase in this fungus. PLoS One, 8. e54893 (2013)
    
    
65. Imamura S*, Hagiwara D, Suzuki F, Kurano N, Harayama S, Genetic transformation of Pseudochoricystis ellipsoidea, an aliphatic hydrocarbon-producing green alga. J. Gen. Appl. Microbiol., 58. 1-10 (2012)
    
    
66. Hagiwara D*, Mizuno T, Abe K*, Characterization of the conserved phosphorylation site in the Aspergillus nidulans response regulator SrrA. Curr. Genet., 57. 103-114 (2011)
    
    
67. Marui J, Yoshimi A, Hagiwara D, Fujii-Watanabe Y, Oda K, Koike H, Tamano K, Ishii T, Sano M, Machida M, and Abe K*, Use of the Aspergillus oryzae actin gene promoter in a novel reporter system for exploring antifungal compounds and their target genes. Appl. Microbiol. Biotechnol., 87. 1829-1840 (2010)
    
    
68. Hagiwara D*, Asano Y, Marui J, Yoshimi A, Mizuno T, Abe K*, Transcriptional profiling for Aspergillus nidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress. Fungal Genet. Biol., 46. 868-878 (2009)
    
    
69. Hagiwara D*, Mizuno T, and Abe K*, Characterization of NikA histidine kinase and two response regulators with special reference to osmotic adaptation and asexual development in Aspergillus nidulans. Biosci. Biotechnol. Biochem., 73. 1566-1571 (2009)
    
    
70. Hagiwara D*, Kondo A, Fujioka T, and Abe K*, Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans. Curr. Genet., 54. 325-338 (2008)
    
    
71. Hagiwara D*, Asano Y, Yamashino T, and Mizuno T, Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans. Biosci. Biotechnol. Biochem., 72. 2756-2760 (2008)
    
    
72. Asano Y, Hagiwara D*, Yamashino T, and Mizuno T, Characterization of the bZip-type transcription factor NapA with reference to oxidative stress response in Aspergillus nidulans. Biosci. Biotechnol. Biochem., 71. 1800-1803 (2007)
    
    
73. Furukawa K, Yoshimi A, Furukawa T, Hoshi Y, Hagiwara D, Sato N, Fujioka T, Mizutani O, Mizuno Y, Kobayashi T, and Abe K*, Novel reporter gene expression systems for monitoring activation of the Aspergillus nidulans HOG pathway. Biosci. Biotechnol. Biochem., 71. 1724-1730 (2007)
    
    
74. Hagiwara D*, Asano Y, Marui J, Furukawa K, Kanamaru K, Kato M, Abe K, Kobayashi T, Yamashino T, and Mizuno T, The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans. Biosci. Biotechnol. Biochem., 71. 1003-1014 (2007)
    
    
75. Hagiwara D*, Matsubayashi Y, Marui J, Furukawa K, Yamashino T, Kanamaru K, Kato M, Abe K, Kobayashi T, and Mizuno T, Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans with special reference to fungicide responses. Biosci. Biotechnol. Biochem., 71. 844-847 (2007)
    
    
76. Hagiwara D, Yamashino T and Mizuno T*, Genome-wide comparison of the His-to-Asp phosphorelay signaling components of three symbiotic genera of Rhizobia. DNA Res., 11. 57-65 (2004)
    
    
77. Hagiwara D, Yamashino T and Mizuno T*, A genome-wide view of Escherichia coli BasS-BasR two-component system implicated in iron-responses. Biosci. Biotechnol. Biochem., 68. 1758-1767 (2004) (2004年度日本農芸化学会 BBB論文賞)
    
    
78. Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T and Mizuno T*, Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. J. Bacteriol., 185. 5735-5746 (2003)
    （ * 責任著者）